AustralieFrV1, Main, Exploration, bibRecord, 006B60

Effect of heart rate reduction by ivabradine on left ventricular remodeling in the echocardiographic substudy of BEAUTIFUL

Identifieur interne : 006B60 ( Main/Exploration ); précédent : 006B59; suivant : 006B61

Effect of heart rate reduction by ivabradine on left ventricular remodeling in the echocardiographic substudy of BEAUTIFUL

Auteurs : C. Ceconi [Italie] ; S. B. Freedman [Australie] ; J. C. Tardif [Canada] ; P. Hildebrandt [Danemark] ; T. Mcdonagh [Royaume-Uni] ; P. Gueret [France] ; G. Parrinello [Italie] ; M. Robertson [Royaume-Uni] ; P. G. Steg [France] ; M. Tendera [Pologne] ; I. Ford [Royaume-Uni] ; K. Fox [Royaume-Uni] ; R. Ferrari [Italie]

Source :

International journal of cardiology [ 0167-5273 ] ; 2011.

RBID : Pascal:11-0100745

Descripteurs français

Pascal (Inist)
- Pathologie de l'appareil circulatoire, Rythme cardiaque, Réduction, Ivabradine, Ventricule gauche, Remodelage vasculaire, Echocardiographie, Cardiologie.

English descriptors

KwdEn :
- Cardiology, Cardiovascular disease, Echocardiography, Heart rate, Ivabradine, Left ventricle, Reduction, Vascular remodeling.

Abstract

Aims: Occlusive coronary artery disease (CAD) is associated with left ventricular (LV) remodeling, LV systolic dysfunction, and heart failure. The BEAUTIFUL Echo substudy aimed to evaluate the effects of heart rate reduction with ivabradine on LV size (primary end-point: change in LV end-systolic volume index [LVESVI]) and function and the cardiac biomarker N-terminal pro-brain natriuretic peptide (NT-proBNP). Methods and results: The substudy was carried out in 86 centers participating in the BEAUTIFUL study. 2D echocardiography was performed at baseline, and after 3 and 12 months in patients with stable CAD and LV systolic dysfunction receiving ivabradine or placebo at the same time-points. All data were read and analyzed centrally. Of 525 patients completing the study, 426 had adequate echocardiographic readings (n=220 ivabradine; n = 206 placebo). Treatment with ivabradine was associated with a decrease in the primary end-point LVESVI (change from baseline to last value, - 1.48 ± 13.00 mL/m²) versus an increase with placebo (1.85 ± 10.54 mL/m²) (P = 0.018). There was an increase in LV ejection fraction with ivabradine (2.00± 7.02%) versus no change with placebo (0.01 ± 6.20%) (P=0.009). Reduction in LVESVI was related to the degree of heart rate reduction with ivabradine. There were no differences in any other echocardiographic parameters or NT-proBNP. Change in LVESVI was related to the log change in NT-proBNP in the ivabradine group only (r=0.18, P=0.006). Conclusions: Our observations suggest that ivabradine may reverse detrimental LV remodeling in patients with CAD and LV systolic dysfunction.

Affiliations:

Australie, Canada, Danemark, France, Italie, Pologne, Royaume-Uni
Angleterre, Grand Londres, Nouvelle-Galles du Sud, Écosse, Île-de-France
Créteil, Glasgow, Londres, Paris, Sydney
Université de Glasgow, Université de Sydney

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Le document en format XML

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<series><title level="j" type="main">International journal of cardiology</title>
<title level="j" type="abbreviated">Int. j. cardiol.</title>
<idno type="ISSN">0167-5273</idno>
<imprint><date when="2011">2011</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cardiology</term>
<term>Cardiovascular disease</term>
<term>Echocardiography</term>
<term>Heart rate</term>
<term>Ivabradine</term>
<term>Left ventricle</term>
<term>Reduction</term>
<term>Vascular remodeling</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Pathologie de l'appareil circulatoire</term>
<term>Rythme cardiaque</term>
<term>Réduction</term>
<term>Ivabradine</term>
<term>Ventricule gauche</term>
<term>Remodelage vasculaire</term>
<term>Echocardiographie</term>
<term>Cardiologie</term>
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<front><div type="abstract" xml:lang="en">Aims: Occlusive coronary artery disease (CAD) is associated with left ventricular (LV) remodeling, LV systolic dysfunction, and heart failure. The BEAUTIFUL Echo substudy aimed to evaluate the effects of heart rate reduction with ivabradine on LV size (primary end-point: change in LV end-systolic volume index [LVESVI]) and function and the cardiac biomarker N-terminal pro-brain natriuretic peptide (NT-proBNP). Methods and results: The substudy was carried out in 86 centers participating in the BEAUTIFUL study. 2D echocardiography was performed at baseline, and after 3 and 12 months in patients with stable CAD and LV systolic dysfunction receiving ivabradine or placebo at the same time-points. All data were read and analyzed centrally. Of 525 patients completing the study, 426 had adequate echocardiographic readings (n=220 ivabradine; n = 206 placebo). Treatment with ivabradine was associated with a decrease in the primary end-point LVESVI (change from baseline to last value, - 1.48 ± 13.00 mL/m<sup>2</sup>
) versus an increase with placebo (1.85 ± 10.54 mL/m<sup>2</sup>
) (P = 0.018). There was an increase in LV ejection fraction with ivabradine (2.00± 7.02%) versus no change with placebo (0.01 ± 6.20%) (P=0.009). Reduction in LVESVI was related to the degree of heart rate reduction with ivabradine. There were no differences in any other echocardiographic parameters or NT-proBNP. Change in LVESVI was related to the log change in NT-proBNP in the ivabradine group only (r=0.18, P=0.006). Conclusions: Our observations suggest that ivabradine may reverse detrimental LV remodeling in patients with CAD and LV systolic dysfunction.</div>
</front>
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   |texte=   Effect of heart rate reduction by ivabradine on left ventricular remodeling in the echocardiographic substudy of BEAUTIFUL
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	Serveur d'exploration sur les relations entre la France et l'Australie
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Effect of heart rate reduction by ivabradine on left ventricular remodeling in the echocardiographic substudy of BEAUTIFUL

Effect of heart rate reduction by ivabradine on left ventricular remodeling in the echocardiographic substudy of BEAUTIFUL

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